Neale Lab Research

The research of Neale Lab focuses on the discovery and understanding of function of genes in forest trees, especially those controlling complex traits, through genetic mapping and genomic science technologies. In the very near future, nearly all the genes in pine will have been cloned and their DNA sequences determined. The cloned genes will serve as tools for functional analysis which will lead to undertstanding of complex patterns of coordinated expression of genes leading to phenotype. Initially, we have focused on traits of practical value such as wood quality, growth,and disease resistance but we expect to expand our studies to identifying genes determining patterns of adaptation and response to environmental stresses.


    Wood stiffness is the most important property of structural lumber. Wood characteristics are particularly important...

    The ACE-SAP project involves the study of biological and genetic diversity in some plant and animal populations as well as aquatic systems of Trentino....

    The goal of the Allele Discovery of Economic Pine Traits (ADEPT) project is to develop an infrastructure for identifying alleles at candidate gene loci that can...
  • ADEPT2

    Our long term goal is to genetically dissect complex traits and understand the relationship between naturally occurring genetic and phenotypic variation in forest trees...
  • Agenda2020

    Wood stiffness is the most important property of structural lumber. Wood characteristics are particularly important...
  • CCGP

    We have formed an international collaboration called the Conifer Comparative Genomics Project (CCGP). The immediate goals of this project are to...
  • CRSP

    Goal #1, Develop further the bioinformatic, genomic and database resources for a Pinaceae comparative genomics infrastructure...
  • CTGN

    Conifer Translational Genomics Network
  • Dendrome

    Dendrome is a collection of forest tree genome databases and other forest genetic information resources for the international forest genetics community.
  • DFGP

    In the Douglas-Fir Genome Project we propose to use a population genomic approach called association mapping to identify the specific genes that are...

    US forests are being challenged by many natural and anthropgenic stresses, including introduced pathogens and insects, climate change...
  • LPGP

    The Loblolly-Pine Genomics Project is a multi-institutional network of research collaborators with a common and well-defined set of genomics research goals...
  • PBGP

    The DOE's Breaking the Biological Barriers to Cellulosic Ethanol report identifies poplar as one of the key...
  • PGP

    Traditional pear breeding, like most woody perennial crops, takes a long time due to the breeding life cycle time and time to trait evaluation and can be...
  • SSGP

    This project aims to begin to investigate the genetic basis of adaptation in coast redwood using genome-based tools...
  • WGMB

    This project aims to begin to obtain the genome sequence of walnut (Juglans regia), cultivar 'Chandler'. Additionally...

    The goal of this study is single nucleotide polymorphism (SNP) discovery in the North American members of the white pines (Pinus section strobus)...

Upcoming Events


Latest Publications

A. Carrasco, J.L. Wegrzyn, R. Durán, M. Fernández, A. Donoso, V. Rodriguez, D.B. Neale, S. Valenzuela (2017) Expression profiling in Pinus radiata infected with Fusarium circinatum. Tree Genetics and Genomes. 13:46-46. Full Text.
B.M. Lind, C.J. Friedline, J.L. Wegrzyn, P.E. Maloney, D.R. Vogler, D.B. Neale, A.J. Eckert (2017) Water availability drives signatures of local adaptation in whitebark pine (Pinus albicaulis Englm.) across fine spatial scales of the Lake Tahoe Basin, USA. Molecular Ecology. :-. Full Text.
D. B. Neale, P. J. Martinez-Garcia, A. R. De La Torre, S. Montanari, X. Wei (2017) Novel Insights into Tree Biology and Genome Evolution as Revealed Through Genomics. Annual Review of Plant Biology. 68:1-1. Full Text.
A. V. Zimin, K. A. Stevens, M. W. Crepeau, D. Puiu, J. L. Wegrzyn, J. A. Yorke, C. H. Langley, D. B. Neale, S. L. Salzberg (2017) An Improved Assembly of the Loblolly Pine Mega-Genome Using Long-Read Single-Molecule Sequencing. Giga Science. 6:1-4. Full Text. Supplemental.
J.S. Xiong, S.E. McKeand, F. Isik, J. Wegrzyn, D.B. Neale, Z. Zeng, L. da Costa e Silva, R.W. Whetten (2016) Quantitative Trait Loci Influencing Forking Defects in an Outbred Pedigree of Loblolly Pine. . 17:138-138. Full Text.
C. Vangestel, A. Vázquez-Lobo, P.J. Martínez-García, I. Calic, J.L. Wegrzyn, D.B. Neale (2016) Patterns of neutral and adaptive genetic diversity across the natural range of sugar pine (Pinus lambertiana Dougl.) . Tree Genetics and Genomes. 12:51-51. Full Text.
S.T. Kujala, T. Knürr, K. Kärkkäinen, D.B. Neale, M.J. Sillanpää, O. Savolainen (2016) Genetic Heterogeneity Underlying Variation in a Locally Adaptive Clinal Trait in Pinus sylvestris Revealed by a Bayesian Multipopulation Analysis. Heredity. 115:1-1. Full Text.
K.A. Stevens, J. Wegrzyn, A. Zimin, D. Puiu, M. Crepeau, C. Cardeno, R. Paul, D. Gonzalez-Ibeaz, M. Koriabine, A. Holtz-Morris, P. Martinez-Garcia, U. Sezen, G. Marcais, K. Jermstad, P. McGuire, C.A. Loopstra, J. M. Davis, A. Eckert, P. deJong, J.A. Yorke, S.L. Salzberg, D.B. Neale, C.H. Langley (2016) Sequence of the Sugar Pine Megagenome. Genetics. 204: - . Full Text. Supplemental.
D. Gonzalez-Ibeas, P.J. Martinez-Garcia, R.A. Famula, A. Delfino-Mix, K.A. Stevens, C.A. Loopstra, C.H. Langley, D.B. Neale,J.L. Wegrzyn (2016) Assessing the Gene Content of the Megagenome: Sugar Pine (Pinus lambertiana). G3: Genes|Genomes|Genetics . 1: - . Full Text. Supplemental.
Maloney P.E., Eckert A.J., Vogler D.R., Jensen C.E., Delfino Mix A., Neale D.B. (2016) Landscape Biology of Western White Pine: Implications for Conservation of a Widely-Distributed Five-Needle Pine at Its Southern Range Limit. Forests. 7:93-102. Full Text.

Latest Meeting Abstracts

Martinez-Garcia P.J., Stevens K., Wegrzyn J., Liechty J., Crepeau M., Langley C., Neale D. 2013. A Comprehensive High-Density Genetic Linkage Map For Loblolly Pine (Pinus taeda L.). International Plant & Animal Genome XXI. January 12 - January 16, 2013.
Mockaitis K., Fuentes-Soriano S., Loopstra C., We J., Neale D. 2013. Building References For Functional Genomics Of Conifer Development: Deep Sequencing and Comparative Gene Expression In Reproductive Tissues and Seeds Of Loblolly Pine. International Plant & Animal Genome XXI. January 12 - January 16, 2013.
Wegrzyn J., Lin B., Zieve J., Stevens K., Neale D., Martinez-Garcia P.J., Dougherty M. 2013. Insights Into The Loblolly Pine Genome: Characterization Of Fosmid Sequences. International Plant & Animal Genome XXI. January 12 - January 16, 2013.
Wegrzyn J., Figueroa B., Yu J., Vasquez-Gross H., Liechty J., Lin B., Zieve J., Ip J., Neale D. 2013. P-0948 Bioinformatic Solutions in Forest Genomics: Accessing the TreeGenes Database. International Plant & Animal Genome XXI. January 14, 2013.
Kaya Z., Gulsoy A.D., Ulug A., Wegrzyn J., Neale D. 2013. P0760 - SNP Diversity of Candidate Genes Encoding Cellulose and Lignin Biosynthetic Enzymes in Populus nigra Clone Bank in Turkey: Its Implications for Conservation and Breeding. International Animal & Plant Genome XXI. January 14, 2013.